That would be the Channel # 2 and 5 bridges on the US 1 highway going to the keys. If you use live baby blue crabs you'll get Permits, too. Sharks, Barracudas, Groupers, and snappers are abundant there.
If you're looking for a big fight, fish cut bait on the bottom at ebb tide and hook a sting ray and spend the rest of the day or night reeling it in.