I have it out of both my 305 and 405. Figured itd help the flow a little bit. It doesnt really ruin the seal either, and whats posted above unless i misunderstood isnt right. When you wanna take your canister off you tank, there is two levers at the bottom. First one you have to move cuts off flow, second detaches hoses from canister. Go clean, return, rehook and plug in and your back filtering again. Done it countless times on both of my tanks and both of my filters. What it does do, is make priming and starting a completely empty canister very tough. When you use the plunger to suck in water, whatever is left on the in tank side of the hose would just drain back in, rather than stay in the hose making the next pump more effective. However, I always fill my canister back up with tank water after cleaning, then rehook it, plug it in and immediately open the flow lever and its starts running just as it was before. No need to yank on the goofy primer.