Yes, once or twice a day is a LOT more than I was thinking too.
It doesn't sound to me like your fish was eating enough, that, and if the food lingers in the tank for any period of time some of those meds are leaching out of the food. It's a powerful tasting/smelling food, and some fish definitely won't find the taste appealing. I fed twice a day, exclusively, for 3-4 days, to fish that would eat it fairly eagerly. The last fish that I used it on came to me in this condition, and thank goodness he ate it like it was his last meal, and he still required 3 treatments before he completely stopped shedding clear/curly poop. He's been 100% free of issues for several months now, so definitely happy with the results, again.