Can't believe that this hasn't been suggested yet, but i would check out hemorrhagic septicemia. Its a bacterial infection very common in wild caught polypterus. It is generally associated with an external parasite called macrogyrodactylus worms. I had bout of this about a year ago and it was NASTY. If you do infact have these worms, they can lay dormant for months before spreading, but when they do, they can kill in days. If you do have these worms, treat with praziquantel.
Even if you don't have these external parasites, hemorrhagic septicemia is still a big possibility from what you've described. Unlike the worms, it can manifest in only a few hours. It is usually seen in polypterus as a secondary infection, usually due to some larger issue (water quality, parasites, injury, etc.). Possibly from the poor quality of your well water? In my experience this disease can be easy to treat if caught quickly, but the longer that its left alone, the more aggressive it can become. I have had success with sulfathiazole and have heard of other reports of success in polypterus by treating with tetracycline.
I would say it up. There are quite a few threads about both macrogyrodactylus and hemorrhagic septicemia on the polypterus section of this forum. Before moving forward with any treatments, i would compare your current symptoms to these two diseases.