I have kept four species of Geophagus before (Jurupari, Surinamensis, red hump and Iporangensis) . The first two developed HITH, and the last two were fine. Geophagus is a large genera fish that came from black water to hard water habitats. My tap water has GH 4 - 6, KH 4 - 5, TDS 130 - 190, and pH 7.2 - 7.6. Apparently, the black water species did not fair well in my slightly hard water.
I have never kept Topajos, so don't know how they will do in my water. But I have witnessed HITH in Topajos, surprisingly in a Florida fish farm breeding facility. The fish farm did not amend RO water for the Topajos, so apparently minor HITH does not affect their growth or procreation. My Surinamensis, dispite HITH, grew to 10 inch fish. He was the dominant fish in the tank in which I changed 75% weekly, so stress and poor water quality can be ruled out as the cause for HITH. If the OP is successful to reverse HITH with RO amendment, then water chemistry must have something to do with HITH.