Technically it would be fine, but personally i wouldn't do it. As far as bottom dwelling fish go, i have 2 clown loaches, 8 albino corys, 3 panda corys, 1 sailfin pleco, 3 otos, 7 clown plecos in my 5ft long main 125gallon tank and that to me looks busier enough (although i want to get 1 more clown loach, posibly more, as they do best in trios or more).
Loaches like being in decent sized groups of their own kind, however they also like to have a lot of space too; over-crowding the bottom of the tank with bottom dwelling fish wouldn't be good even if they were peaceful with each other. I think how many loaches you went for would depend on what kinds of loaches you want exactly, what types of loaches are you interested in?