Yes theoretically but unless you have a cheap way of getting tons of sugar then it's going to end up costing you more than a pressurized co2 system very quickly. Take it from me i tried it on a 150 gallon tank and i figured to prodcue significant amounts of co2 (5-6 bubbles per sec) i needed 6 2 liter bottles (at least) think about how many more bottles you will need on a 220 gallon tank maybe 9 or 10 total. And then think of all the sugar you will have to use it'll end up costing more than the whole pressurized set up within a couple months.
if it's worth doing it's worth doing right!
Go pressurized or go home. (that should be the motto of all planted tank enthusiasts)