Chopper_Kingpin;1418830; said:
Monty Python actually did a sketch like that, it was hilarious!!!! Exact polar opposite of that video.
live alien baby (graphic)
- Thread starter toehead11183
- Start date
Monty Python actually did a sketch like that, it was hilarious!!!! Exact polar opposite of that video.
Sad.....that baby is suffering and they laugh.
I don't know how they get away with that video on youtube ?
Here lately they (youtube) have yanked far less graphic videos ?
http://www.emedicine.com/derm/topic192.htm
Background: Ichthyosis fetalis, also known as harlequin ichthyosis (HI), is the most severe form of congenital ichthyosis and is characterized by a profound thickening of the keratin layer in fetal skin. The affected neonate is born with a massive, horny shell of dense, platelike scale and contraction abnormalities of the eyes, ears, mouth, and appendages. This armor limits movement and compromises the protective skin barrier, leaving the newborn susceptible to metabolic abnormalities and infection.
The term harlequin derives from the newborn's facial expression and the triangular and diamond-shaped pattern of hyperkeratosis. The newborn's mouth is pulled wide open, mimicking a clown's smile.
The underlying genetic abnormality in HI has been identified as a mutation in the lipid-transporter gene ABCA12 on chromosome 2. The presence of homozygous mutations in affected individuals supports an autosomal recessive pattern of inheritance.
Immunohistocytochemical examination of the skin reveals characteristic abnormalities in the structure of lamellar granules and in the expression of epidermal keratin.
In the past, HI was uniformly fatal. Improved survival has been achieved with intense supportive care and systemic retinoid therapy in the neonatal period. Patients who survive manifest a debilitating, persistent ichthyosis similar to other autosomal recessive ichthyoses, such as lamellar ichthyosis (LI) or nonbullous congenital ichthyosiform erythroderma.
Pathophysiology: This disease primarily affects the skin. Other systems are significantly compromised by the hyperkeratosis and concomitant deformities. Neonates are often born prematurely.
Marked eclabium and ectropion is present secondary to the taut, unyielding skin. The ears may be absent or poorly developed. The arms, feet, and digits have flexion contractures and may be hypoplastic. The skin barrier is severely compromised, leading to excessive water loss, electrolyte abnormalities, temperature dysregulation, and an increased risk of life-threatening infection. The tight, armorlike scale can restrict respiration. Poor feeding and impaired intestinal absorption are common.
Frequency:
Race: No racial predilection is known. Sex: No increased risk based on sex is known.
I don't know how they get away with that video on youtube ?
Here lately they (youtube) have yanked far less graphic videos ?
http://www.emedicine.com/derm/topic192.htm
Background: Ichthyosis fetalis, also known as harlequin ichthyosis (HI), is the most severe form of congenital ichthyosis and is characterized by a profound thickening of the keratin layer in fetal skin. The affected neonate is born with a massive, horny shell of dense, platelike scale and contraction abnormalities of the eyes, ears, mouth, and appendages. This armor limits movement and compromises the protective skin barrier, leaving the newborn susceptible to metabolic abnormalities and infection.
The term harlequin derives from the newborn's facial expression and the triangular and diamond-shaped pattern of hyperkeratosis. The newborn's mouth is pulled wide open, mimicking a clown's smile.
The underlying genetic abnormality in HI has been identified as a mutation in the lipid-transporter gene ABCA12 on chromosome 2. The presence of homozygous mutations in affected individuals supports an autosomal recessive pattern of inheritance.
Immunohistocytochemical examination of the skin reveals characteristic abnormalities in the structure of lamellar granules and in the expression of epidermal keratin.
In the past, HI was uniformly fatal. Improved survival has been achieved with intense supportive care and systemic retinoid therapy in the neonatal period. Patients who survive manifest a debilitating, persistent ichthyosis similar to other autosomal recessive ichthyoses, such as lamellar ichthyosis (LI) or nonbullous congenital ichthyosiform erythroderma.
Pathophysiology: This disease primarily affects the skin. Other systems are significantly compromised by the hyperkeratosis and concomitant deformities. Neonates are often born prematurely.
Marked eclabium and ectropion is present secondary to the taut, unyielding skin. The ears may be absent or poorly developed. The arms, feet, and digits have flexion contractures and may be hypoplastic. The skin barrier is severely compromised, leading to excessive water loss, electrolyte abnormalities, temperature dysregulation, and an increased risk of life-threatening infection. The tight, armorlike scale can restrict respiration. Poor feeding and impaired intestinal absorption are common.
Frequency:
- Internationally: More than 100 cases have been reported.
Race: No racial predilection is known. Sex: No increased risk based on sex is known.
ihatecrenicichla;1418549; said:
I thought it was-
A. Fake
B. too much mercury in the sater
C. fake
D. thats just terrible... like somebody said, im glad i turned out somewhat normal !
Freeze_Dried_Bloodworm;1419682; said:May God be with them, I can't imagine living like that
he is.
Yeah, kinda innapropriate bringing them into this thread.
I would be mortified if my baby had that disease. I had trouble getting to sleep last night because that image kept popping into my head.
I would be mortified if my baby had that disease. I had trouble getting to sleep last night because that image kept popping into my head.
i saw the show on those little girls.. its just heartbreaking. it looks so painful. they have to do alot of skincare every single day of their lifes, like they have to scrub off all that skin and use special salves.. i cant imagine the pain of it all. and i feel bad for the parents, because ignorant people stare at them and rubberneck all the time.. some ppl can be so rude.
