How could it not?
Human expansion has already wiped put roughly 90% of all the megafauna of this planet, to include an almost complete obliteration of the megafauna of the Americas. Our exodus from Africa is directly responsible for the end-Pleistocene extinction event.
A primary example of how the ecosystems of the worlds could be benefitted by rebuilding an ecosystem is the American Southwest.
In the American Southwest at the end of the Pleistocene, there was a thriving ecosystem that was strongly analogous to that which we see in Africa. There were saber tooth cats, lions, jaguars, three species of probiscids (elephants), multiple camels, all sorts of bovids and a myriad of lesser beasts.
What's left of the American Southeast megafauna? Condors. We spend millions every year to attempt to provide habitat for these birds. The only reason they missed the end-Pleistocene extinction was first feeding on the animals slaughters by humans and later on the cetaceans that occasionally was up on the California shore. Before the end-Pleistocene event, when the American megafauna thrived, these birds could be found as far east as the Atlantic seaboard.
Now here we are, spending millions a year to artificially keep these animals from going extinct. It strikes me as logical to use the preserves already in place and the funds already allocated to restore the habitat. First, bring back camels and bovids. Once they're established, reintroduce lions and jaguars. After a few decades, the problem of feeding the condors slaughtered beef cattle would resolve itself because the niche for which the condor is adapted is once again available to it.
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