Brace yourself for some sticker shock.
The price increase is pretty steep when you get beyond 1" (25.4MM) thick panels. There is also a steep price jump when you go past standard 8'x4' sheets, as that is a more common size of acrylic panels.
A 10'x5' sheet of 2" (50.8MM) thick Cell Cast will likely cost well over $4,000 US per panel. It looks like you would need two panels for your project since the back and bottom of your frame is steel.
This place has a 8'x4' sheet of 2" @ $3,000 US:
http://www.eplastics.com/Plastic/Plexiglass_Acrylic_Sheet_Clear/PLEXIGLASS-ACRYCLR2-000CCM48X96
(I wasn't able to find the size panel that you need on their site, but a 10'x4' @ only 1.5" thick costs $5,000).
A sheet 10'x5' @ 2" thick is going to weigh around 600lbs, so being able to pickup from a local distributor (if one exists) is going to save you a lot on shipping costs.
There's a member on here (Wednesday13) that is in the process of building a steel framed tank...I'll see if I can get him to chime in.
You may be able to shop around and find better prices, but I would be surprised if you could find the size sheets that you need for under $3,000 each.