Alot will depend on how you want to plumb your drains. With three holes you could run a Bean and run your returns up and over the back, or you could run Herbie style and run your return back up through the overflow. Either way, you'll be running one full siphon drain which can handle alot more flow than a line mixed with air.
On my 300, I run a pair of Quiet one 6000's moving about 1200 gph each at 6' head. My drains are dual herbies, but I'm using 1 1/2" drains. These are mostly overkill for my current setup, but I could eventually see upgrading my pumps and or turning it into a reef tank, so i built it for the future.