either gluing method can be good or bad depending on how good you are with it but whatever you find will work. I use weld on #4,#16, and #40 on different jobs. I find the #16 to be the weakest because its easy to create bubbles when applying. #4 is very strong but can take practice to get good at making crystal clear joints. Ive built alot of tanks with #4 before i learned and purchaced the #40. Professionally built aquariums use Weld on #40. This is a 2 part epoxy similiar to #16 and leaves you with a crystal joint every time. Far superior to #4 or #16. With #40 you can build the tank one panel at a time then apply the bottom and top of the tank last. You can even add crystal seams like you would silicone on the inside for extra re-inforcement. I re-inforce all my acrylic tanks in this fashion for peace of mind when i get a used one. I've even put back together exploded tanks lol...#40 is amazing stuff well worth the extra cash for it.