The nitrite is a major problem...I'd guess you have ammonia as well. Don't mess with your filters so much. You're disrupting your biological filtration. Everytime you clean or replace filter cartridges you are removing beneficial bacteria. If the flow of the filter isn't severely restricted, leave them be. Keep up with the waterchanges as you do and your pleco will heal once the ammonia and nitrite are reading zero. I assume you are testing with test strips..,throw them out and buy an API freshwater master test kit.