This is what O2 depletion looks like in a planted community tank I was treating for ick and mistakenly overdosed with Paraguard. Overdosing with Prime/Safe or a number of other products would look the same.
Per instructions on the label (Prime), up to 4x the regular dose may be used in an emergency situation (high ammonia or nitrite) so there is a 'safety margin'. However, as
RD.
mentioned, how much of a margin depends mainly on surface agitation/oxygenation of water, temperature, and whether other reducing agents are being used.
Per instructions on the label (Prime), up to 4x the regular dose may be used in an emergency situation (high ammonia or nitrite) so there is a 'safety margin'. However, as
