This looks like an oceanic setup with the hose barb bulkheads (inside the overflow tower).
Drain the setup via siphon out from inside the the overflow tower. Whatever the lowest point of water is will eventually be held back by the tower or you can drain the whole tank if your makes you more comfortable.
Go to the hardware store and buy some hose barb plugs and a couple hose clamps. Cut the hose 3” beyond the end of the hose portion of the bulkhead and push in your plugs, clamps it and done.
Swapping Out the bulkheads with better threaded ones is ideal but this can work too.