I just did a quick 30 second Google search to get this. A more in-depth search would give you more info, I'm sure. Metro is more for bacterial infections instead of parasitic infections basically.
Here's the description of what Flagyl (Metronidazole) is for in fish:
Metronidazole 250 mg is for the control of some common bacterial fish diseases. Effective against aeromonas and pseudomonas genera and mysobacterial group (gill diseases chondrococcus)
And here's what it says for Praziquantel:
Prazi is extremely effective for the treatment of external flukes, liver flukes, internal parasites and internal worms in koi, goldfish and tropical fish. Prazi is a one time treatment and because it is so gentle, it does NOT require any water changes after treatment and you do NOT need to bypass your biofilter. Prazi also will work with any amount of salt in the pond and it is not water temperature dependant.
One treatment, not two. No water changes needed
Safe for all species of non food fish including Orfe, Goldfish and Rudd.
No filter or reef bio-filter effects
Deworms cestodes, anasakis, capillaria and other intestinal parasites as well.