I don't know never had to make sure to remove carbon when you applying the medication and do a water change every 2-3 days that's how I do it but not big ones I do 25 -30 % and fill it back up with warm water to keep the temp in the mid 80s
Remove carbon for both meds the melafix and quick cure requires you to remove the carbon out your filter until treatment is over but I'll still use salt