bottom line, don't follow the directions and dose only the water you are changing, if your fish don't die you are good otherwise you know you have to dose the total system volume next time 

That is not correct. It seems even Hagen agrees to dose based on the full aquarium volume and not just what is being replaced when performing a water change directly in tank.
An email I sent them and the reply from Hagen.
( bsp.brentsmithphotography@gmail.com 12/22/2011
I know you have directions for dosage when treating new water first before introduction to an aquarium on your labels but I was wondering if I should dose on the complete aquarium volume with your product when I perform an in tank water change. Say a 100 gallon tank with weekly water changes of 50%.
Brent Smith
Reply:
no-reply@hagencrm.com
Tanya Schwab (Hagen Customer Service Rep) 12/23/2011
Thank you for taking the time to contact us.
Correct. The dosing instructions for water changes consider the total gallon size of your aquarium - not the amount of water changed.
Regards,
Customer Service
Rolf C. Hagen Inc. )
Adding chlorinated (or chloraminated) water directly to your tank gives the free chlorine a chance to react with your fishes' gills before being neutralized by the dechlorinator. It's not an instant reaction so the greater the concentration of dechlorinator, the faster it's dechlorinated. It might be more work to mix the tap water and dechlorinator ahead of time outside the tank but this is not a hobby for the lazy.
4 is the best, but it would kill any monster tank owner wahaha!
this is also why it is safe to rinse filter media quickly under the tap with no ill effects. letting it soak for a while is another story![]()
Really? Which brand is better? OF New water guard vs api vs prime?I usually use method 1 . Once I drain the water from the tank (say 40%), then I add the enough prime (anti chlorine chemical) for the whole tank, wait 15 minutes, then add the new water with the hose straight from the outside faucet. Never had an issue in all my 30+ years of fish keeping..