On my 225 setup I have two custom internal filters and 3 HOB aquaclear 110s. On the HOBs I have the extension tubes with sponge prefilters. Each hob has bagged bio ceramic (4) and one bag of phosguard. On the top of the "sandwich" I lay custom filter pads for mechanical filtration. During water changes I just remove the filter pads and rinse. All bio media is untouched. Put 'em back on, place the tops back and its good to go. On the corner filters I have power heads directed right at the waterfall overflow. Haven't vaccumed the sand in months, no problem and no detrius buildup. Here and there I scoop up Oscar poop with a net but that's pretty rare. The food and poop breaks up and goes right into the filters. Also helps to have two sizeable syno catfish to clean up extra pellets.