Lets clarify something else...putting life in your DSB does not take waste out. In fact, in the long term, it will only accumulate more waste.
Life will die in your DSB, food will rot in your DSB, and so will anything else that can get down to the sand. Fact.
What happens to this? It stays there, and rots.
Because of this, I would rather keep the sand clean, but maybe that is just me.
Remember people, you have a small, closed system, to which you add a ton of nutrients, waste, and food to. Somethings gotta come out sooner or later, and its all ending up in your sand bed.