We've been running our 400 without lids for about a month and haven't seen any problems yet. Then again, we're in the dead of winter here but the tank is in the basement where it's about 56F and the tank is around 74-76. I have yet to see any condensation on the walls or pipes. The guy we bought it from didn't run lids either and kept discus in it at around 84F year round and didn't run into any problems. He also had a 350, 140, and four 75s and didn't have any mold problems. Humidity? definitely, but it didn't cause problems. Once again, we are talking northern WI here and it stays dry for most of the year, but we have some wicked seasons here both ways.