I'm not sure its always genetics neccisarily I wonder if its insufficient/improper nutrition. But in a nutshell.. poor husbandry is where I'de wager 90% of deformed large cats come from. either poor water quality, food, tank space.. or often a combination of 2 or all. The only time I've had issues with large cats health wise was when I had a filter crash on me... I haven't had a significant amount of big cats to really guage how often genetic issues come into play but I've seen plenty of obviosuely stunted/poorly kept ones with physical defects ect... imo TSNS and other active predatory cats are best housed like sw sharks.. in large round/oval enclosures opposed to 4 walls. I have noticed a difference in my hybrid and tsn since moving them to my round pool. not just how much calmer they are now w/ plenty of space but when they do freak on occasion they hit the wall and slide along it instead of being stopped by it. So they don't "Hit" it.
with a custom tank might be worth checking how much extra it would cost to have it a double bullnose ( ie rounded at each end) if your main reason is to house big cats like TSNs. or at least make sure there will be a large enough hide spot the cats will feel less inclined to spook.
Thanks that's definitely something I will think about, and I plan to have the tank decorated with large pieces of driftwood and hopefully some very robust plants but I will just have to see what works lol
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