You need to clean the XP3 at least once every 2 weeks it clogs up very fast. And cleaning the filter will not kill BB as long as you place the bio media in a bucket with tank water.
You should run your XP3 like this...
Bottom tray: 2 sponges (20/30), then bio media on top of that
Middle tray: All bio media
Top tray: 3/4 bio media then microfiltration pad
You should run your XP3 like this...
Bottom tray: 2 sponges (20/30), then bio media on top of that
Middle tray: All bio media
Top tray: 3/4 bio media then microfiltration pad