I usually try and do it on Sunday when I'm hungover and don't have to use my brain for anything, although I have made some pretty ridiculous mistakes doing it in that state of mind. If not on a Sunday then Wednesday since I get the day off.
I have a bare bottom, so I only vac when it gets messy, as of now the tank gets like 40 minutes of light a day so no algae is growing. I do 50% WC on Fridays after work, and clean the mech filter every 2 or 3 weeks.