You think having two fx4s is better than one fx6?
Yes, but why not go with two FX-6? The price isn't much different. Unless you already own them. With a big tank, you want two, so that you can have an intake and return near either end. With only one FX-6, you would likely need something else like a power head to create more circulation.
How often do you have to clean the tank?
It's not set up yet, but I'm expecting that I'll do weekly 60-70% water changes and clean or replace the fine filter pad in the top of the canister every two weeks. Maybe vacuum the gravel once a week.