no I haven't had any problems yet. She has been fine in the eco-complete sand and in the red flint sand I had her in before. I was a little worried about the eco-complete because underneath the gravel the sand is really fine, but I havn't had any problems yet.
When I had her in the red flint sand, it would sometimes stick to her but it would stick to the slime coat, and it really didn't seem irratating to her.