As long as there is no downward flexing in the middle for the 48" that should work. For reference, my 8 ft 240g acrylic has a wooden stand (built by a carpenter who builds wooden aquarium stands) with supports along the edges and finished off with a plywood top (don't know if it's 1.5" or 2" thick). There's no beam that goes across the middle (front to back) under the plywood top and I haven't seen any middle sagging in the last 9 years.
The 72" is fine, and I would go with that config.
The 72" is fine, and I would go with that config.