Dempsey's have been the most aggressive of any cichlid I've owned(GT's, Firemouths, Convicts, Nicaragua's, oscars...), but have also been the coolest in interacting. The Danios may act as decent dither, but once he hits a good size he wont care about them at all and only show aggression toward similar sized fish.. Also this doesn't seem to be the norm, but my Jack hates pleco's, I've tried common, hi-fin, and brushnose and all were destroyed. But he doesn't mind my African featherfin cat which looks a lot like a pleco. My jack was a tride and true killer in his youth (6-8") but now at 2yrs old seems to have calmed down alot, and doesn't bother any tank mates(haven't tried plecos again though).