Bioballs will work. There's so much room in the fx5 compartments to work with. One thing my pet supplier (owner) told me...can use legos. I did with my sump for the 265g, and it works great too. Bioballs can add up too as they are a bit pricey. You just need to fill in the space loosely to have the good bacteria to build up and thrive in....or scrubbie pads work too....
With my 125g, I tried using just the fx5. I want/need (ocd) to see all the plants in the tank sway. Didn't cut it. Right now I have the fx5, UV sterilizer, AC 110, and fluval U4 (submersible) all in it. Fishies are happy. Better to go a lil' overboard with the filtration...