I´m with Jexnell on this,
to me a seldom cleaned canister becomes a production house for elevated nitrate, compared to a couple frequently cleaned HOBs.
Once a tank is cycled, nitrate is the most toxic substance we end up in our aquariums.
I consider any nitrate level above 10 ppm as toxic, because in nature nitrate is almost always < 1 ppm.
I have been testing natural waters from Lake Michigan to Costa Rica, to the Cenotes in Mexico, for more than 20 years.
and in all those places (unless the water is considered polluted, usually by excess fertilization, or excrement (human or animal)),
nitrates are always undetectable.
I now ive in Panama where I test every river where I collect my fish.
In every watershed where have collected , and found healthy species, nitrates have been undetectable.
Below are a number of tests from water samples in Panama. (yelloe are nitrate, red pH)

