Interesting build and you're right to be concerned with the loab bearing abilities of the slab. Something that a lot of the random people mentioning comparing cars weight to the tank weight that they clearly don't know is there is a BIG difference between dead load (aquarium) where its a continuous load and the occasional load of your car on the garage floor regardless of the surface area the load is being distributed upon. A slab that's meant to hold 5000lbs occasionally will end up breaking over time if it's forced to hold a continuous 5000lb load.
Also the other thing that's been mentioned is what's under the slab. I saw another members thread with two huge acrylic tanks where the weight of the tanks actually sank one side of the slab down and caused huge problems because the tanks became unlevel.
You should be able to find the proper 1950's building codes somewhere online that would list the minimum requirements for residential construction concrete slabs and use that as a worst case scenario for thickness/load capabilities. Standard residential slab construction is 4". Really heavy load bearing concrete slabs are recommended to be 5-6" thick.
http://concreteconstruction.net/industry-news.asp?sectionID=714&articleID=540592
Best of luck with the build, I'll be tracking this thread as I'm sure it will be epic when complete!
~Trent