Every hobbyist that has fed their tropical fish, foods that contain ethoxyquin, over a lifetime of 10, 15, and in some cases 25+ years, have taken part in a long term feed safety study.
Exactly, and certain general conclusions can be drawn from this well as from scientific aquaculture study.
1. Water quality and water related factors are highly important to fish health and longevity.
2. Feeding levels and protein levels are important to fish growth and health. Overfeeding and too high or too low protein levels have negative effects on fish health, growth, and longevity. Some of these are internal, such as fatty liver.
3. Certain ingredients, such as soy based meal and flour, etc., have limited tolerance by fish, varying by species. One of the studied negative effects is intestinal inflammation. Certain combinations of ingredients, soy and peas, for example, also cause negative effects. This is well documented and has been the subject of ongoing study as commercial aquaculture attempts to find alternative feed and protein sources. Example:
https://www.sciencedaily.com/releases/2013/12/131203090706.htm
The increased use of plant materials results in many cases to less growth and presents a hazard to the digestive health of many fish species, including salmon.
From my perspective, that controlled lab studies of EQ with fish hasn't been done does leave some open questions, such as whether there are unknown long term sub-lethal health effects at approved levels, whether some species or individuals are more sensitive than others, whether certain nutrients provide some protection from potential negative EQ effects or whether certain ingredients in combination with EQ increase the risk. I'm also open to the possibility that more than one fish food has higher than FDA approved levels of EQ. But without clinical study or positive data, it leaves the answers to these things in the realm of opinion or conjecture.
What seems apparent overall, at least if you've been in the hobby long enough, is that it's easier to keep fish healthier and living longer with the foods, equipment, and nutritional science we have today than it was 40-50 years ago.