Up until recently I only used Microbe-Lift products for everything and it worked great, no smell and chemical free. The only issue I had is when they started adding ammonia to the tap water then my Microbe-Lift Dechlorinator just wasn't cutting it, so I have to use Prime until I can find a better alternative. I do have ML ammonia remover but it's only small bottle and it can't remove all the ammonia unless I double dose it. I heard they do have an heavy duty version that is for higher amounts of ammonia but no place sells it. I have my usual place that sells most ML products, all but that one I need to remove ammonia. Even though prime works, I still would rather not use it mainly because 1. it's a chemical and 2. the marketing hypes claims to remove ammonia but really it only makes it temporarily safe, sorry but that's not good enough for my aquarium. Microbe-Lift imo is by far the best water conditioner products period, they are just hard to find products. I really miss using ML, it was a joy to work with and they have a solution for every aquarium need. I may beg for the online store to carry the item I need. I try to buy the 16 oz because they last longer.
I may go the Safe route in the future, but I'm looking at alternatives at the moment for an auto water change system. 
