Not if you buy Seachem Safe. It is the only thing I use. I do a lot of water changes. I mean a lot. A bottle of Safe, 1kilo(2.2lbs) for $30 treats...get this....200,000 gallons. Actually they just retested this product and it will treat 300,000 gallons at 4ppm chlorine which is A LOT of chlorine and most water systems don't treat at that high a dose. Mine on average last year was around 1.35ppm chlorine.See this is my problem. De-cholr the entire tank? No way! That's just not right. And with the amount of water changes I need to do, that would get expensive really quick.
Spend the money and but the Safe and it will last you forever. One container lasts me about a year. $30 a year when doing weekly 85% water changes on my tank is a huge savings.
PS...it is the concentrated version of Seachem Prime and about 10 times as potent.