Hello; I rarely use water conditioners. I am lucky to have water treated only with chlorine. I fill jugs with the tap water and allow it to sit for a week or more to use for my Water changes. Don't have acid water as i live in a Karst ( limestone) area.
For decades I have only used Prime or Safe at select times. If I have to set up a tank in a hurry and use water straight from the tap I use some. If I breakdown a tank to decontaminate the tank, equipment and substrate with clorox, I use some Prime or Safe. Even after a good rinse there can be a clorox residue. I find some thorough rinsing is needed to be sure, but some Prime when the tank is first filled is also sometimes needed.
For decades I have only used Prime or Safe at select times. If I have to set up a tank in a hurry and use water straight from the tap I use some. If I breakdown a tank to decontaminate the tank, equipment and substrate with clorox, I use some Prime or Safe. Even after a good rinse there can be a clorox residue. I find some thorough rinsing is needed to be sure, but some Prime when the tank is first filled is also sometimes needed.