You mention "easiest and safest" in your opening post. The guys have pretty much covered how easy it is, I thought i'd add a few points regarding safety, for your home and your fishes perspective.
1. When doing water changes DO NOT scuttle off to just do this job or finish that job. Distractions during water changes usually end with water on the floor!
2. If lids are removed always be aware of fish that may jump.
3. Don't forget water conditioner.
4. When draining I fix some plastic mesh over the end of my hose with cable ties. This stops inquisitive smaller fish from getting sucked to their deaths down the drain.
5. If heaters need to be switched off beforehand, make sure to switch them back on afterwards.
6. If your boiler is anything like mine, DO NOT set the temperature of the water and just let it fill without checking regularly, especially if other people in the house turn taps on in other rooms. The water temp can drastically change as you're filling. That is very bad.
Just a few pointers that have served me, my home and my fish very well.