note sure never owned either.according to the labels on the meds it says it would be safe to use with other meds.. as for epson salt it just aides in digestion and making the fish a bit hungry. tank salt i use everytime i change water. i have only used the epson salt when there was a internal parasite issue. same with prazi pro and metro. come to think of it i have use jungles parasite clear with prazi and metro with the epson salt. my rapheal cats never died .