The symptoms before death was mostly fungus and or fin and tail rot. Back when i first started getting them everyone was telling me this (IMO) nonsense about Hydrolycus were very fragile to medication and not to use anything except salt and high temps.
So my first 4 attemps were with a single specimen and it allways ended the same. The fish would seem just fine for a few weeks and then one day it would be covered in fungus or have bad fin rot. So i would add salt and start to raise the temp and within 2-3 days they would be dead.
After that I starting using antibiotics regularly. I would drip acclimate the new scombs to my tank with antibiotics in the bucket as well as mythelyne blue. i would do this for around 2 hours on a slow drip.
That seemed to work as the fish would not get a illness for several months. And then one day they would get ripped up fins and then fin rot and die.
I never had any ammonia or nitrite but my nitrate from the tap is 20ppm and it would stay around that in the tank between water changes. My tank for all these was a standard 75g and i have 35x turn over rate going with 2 emperor 400gph HOB filters and 1 350goh canister filter and 2 power heads that were connected to sponge filters. i also tried them with many many live plants and no aireation as well as with fake plants and 4 air stones going for oxygen.
The longest i was able to keep one alive was for 1 year and 4 months. It was housed with a TAT that was the same size for the last few months and the scomb came down with a mouth fungus and died with in 24hrs. The tat never got sick one time. The biggest group I had was 3 at one time.
The next time I am able to get a some scombs I plan on trying a very low flow set up with alot of air stones in the sump. I am planning for around a 3x turn over rate. And a leaf litter substrate in hopes that the tannic acids help with the fungus problems. Instead of the 35x turn over rate that i had on the last 10 fish.
What is your set up like?