I was planning something similar (6x4) but I got so frustrated trying to find a cheap 4x2 for sale I gave up and went with a 600 plywood (see sig)
There are a few problems with using a glass panel. They are all surmountable, but please consider them carefully.
1) a 6 foot by 6 foot glass panel will be very heavy - like 400lbs heavy, maybe more. It will also be very awkward to move, and even a tiny bump on the floor will crack it.
2) Making a 6 foot by 6 foot floating bottom would be a lot to ask of your silicone. your silicone seams linking the bottom to the sides will be directly supporting nearly 3 tons of water column. You would have to be sure to support it with foam very carefully to ease the load on the seams.
3) Once assembled, the tank would be nearly impossible to move. Not just from a manpower point of view, but from a twisting/seam integrity point of view. It would need to be assembled in place, because picking it up may tear it apart.
4) 6 foot by 6 foot glass will be pricey in and of itself but the delivery of such a large, heavy object will be difficult as well. You may get dinged heavy transport fees.
As someone else suggested, you would be much better off with a slightly larger than 6x6 fiberglass and plywood base with a notch around it's perimeter for the glass to set into. This is how I had planned to build the 4x6x2 tank, only I was going to tile the bottom, and build a wood frame/canopy for the top rather than use eurobracing.