I think one of the easiest ways is to use uniseal type rubber grommets in the 4" pvc. Uniseals absolutely will not leak if the hole is drilled the right size and the pipe or tubing fits into the uniseal snug.
Here, an 11/16-3/4" hole in the thinwall 4" pvc holds the uniseal. 1/2" cpvc pipe (O.D. 5/8") or 5/8" O.D. vinal tubing fits very tightly into the uniseal. Vinal tubing is a slightly better option than cpvc because it can flex to accomadate the very slight oblong hole in the pvc. (A hole will be slightly elongated in the direction of the bend around the 4" pipe, so I drill a smaller hole (11/16") and use rolled up sand paper to increase the hole diameter mostly in the vertical direction.)
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A 90º elbo extends the input down to the bottom of the 15" tower. The ouput hole is at the top of 4" pvc opposite the input (not pictured).
Hey mike how are the uniseals holding up ?